About 30 vehicles have been involved in a fatal crash on the M40 in Oxfordshire, police have said.
Thames Valley Police has not said how many people have died.
South Central Ambulance Service says it is assessing more than 30 patients at the scene.
An ambulance spokeswoman said it was foggy at the time of the "major collision".
She said it was too early to know the nature and severity of the injuries.
"We have a lot of resources on the scene - ambulances, our helicopter ambulance, rapid response vehicles, our doctor and our hazardous area response team," she said.
"Fire and police are also at the scene."
Police said the road would be closed "for a number of hours" and have warned motorists to avoid the area because of "heavy traffic congestion".
The force said officers were working to relieve traffic stuck on the northbound carriageway.
A couple of southbound lanes are also shut along the same stretch.
On Twitter, Zara Smith, who was stuck at junction 9, said a number of lorries had jackknifed in "thick fog".
"Lots of people were walking around but the police are working hard to turn us round," she said.
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